This would mean that the role individual areas play in shaping each other’s activity could be flexible and tailored to the dynamic demands of behavior. The function of these rapidly changing influences is not yet known, but the authors hypothesize that they may allow cortical areas to control different aspects of processing in the downstream brain regions they influence over very short time spans. For example, a neuron in area V1 could decrease its activity in response to area LM at one time point but not be influenced by LM activity 100 milliseconds later.įurthermore, if the visual stimulus was behaviorally relevant for the animal, for example if it was predicting the occurrence of a reward, then these changes in influence occurred even faster. Surprisingly, they found that the effect of manipulating one area on the activity in another varied over time on a fast timescale. Javadzadeh and Hofer measured these contributions over time while these brain areas were processing visual information. This showed them the contribution of the first area in shaping the firing rates of the second area. The neuroscientists recorded from populations of neurons in V1 and LM in mice and used optogenetics to briefly silence the activity of one area and quantify how the activity increased or decreased in the other area. Measuring changes in the activity of neurons in a cortical area while perturbing the activity in another area. In this study, Javadzadeh and Hofer instead took a causal approach by using neuronal perturbations to study the dynamics of inter-areal interactions over time. Historically, scientists have recorded from different brain areas and used statistical correlations to infer how one area influences another. These changes can happen very rapidly, within tens of milliseconds,” said Sonja Hofer, Group Leader at SWC and co-author on the paper. “Our expectation from the anatomical connections between V1 and LM is that the effect of neuronal activity in one area on another would be relatively constant however, we were surprised to find it is dynamic and changes over time. The first level of hierarchy in the cerebral cortex is V1 and the second level is V2 in primates, the equivalent of which is LM in mice,” said Mitra Javadzadeh, Research Fellow at SWC and co-author on the paper. From classical studies, we know that there is a hierarchy of visual areas with feedforward and feedback pathways. “We wanted to study the communication between areas to understand how different brain regions work together to process visual stimuli. In a new study, published today in Neuron, SWC researchers elucidate how two visual areas in the cerebral cortex, the primary visual cortex (V1) and lateromedial area (LM), influence one another and how this communication changes over rapid timespans. With around 80 billion neurons and 100 trillion connections in the brain, it has been challenging for neuroscientists to untangle the networks that give rise to behavior. Researchers at the Sainsbury Wellcome Centre at UCL used causal techniques to uncover how two neocortical areas in the brain communicate with one another and found that their influence on each other changes over much faster timescales than previously thought. Understanding how brain areas communicate is one of the oldest questions in neuroscience. Summary: Researchers identified how the primary visual cortex and the lateromedial area of the cerebral cortex influence one another, and how this communication changes over rapid timespans.
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